Scintigraphic techniques for early detection of cancer treatment–induced cardiotoxicity

…, M Gotthardt, WJG Oyen, L Kapusta… - Journal of nuclear …, 2013 - Soc Nuclear Med
New antitumor agents have resulted in significant survival benefits for cancer patients.
However, several agents may have serious cardiovascular side effects. Left ventricular …

Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance: JACC CardioOncology State-of-the-Art Review

…, L Bellersen, EC van Dalen, HB Grotenhuis, L Kapusta… - Cardio Oncology, 2020 - jacc.org
Cardiac diseases in the growing population of childhood cancer survivors are of major
concern. Cardiotoxicity as a consequence of anthracyclines and chest radiotherapy …

Primary cardioprotection with dexrazoxane in patients with childhood cancer who are expected to receive anthracyclines: recommendations from the International Late …

…, HB Grotenhuis, JM Leerink, L Kapusta… - The Lancet Child & …, 2022 - thelancet.com
Survivors of childhood cancer are at risk of anthracycline-induced cardiotoxicity, which might
be prevented by dexrazoxane. However, concerns exist about the safety of dexrazoxane …

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

…, P Shaw, H Yeger, I Morava-Protzner, L Kapusta… - Nature medicine, 1997 - nature.com
Breast cancer is the second leading cause of cancer death in North American women. There
is considerable need for reliable prognostic markers to assist clinicians in making …

The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1-Related Breast Cancer

…, N Hamel, JR Goffin, N Wong, M Trudel, L Kapusta… - Cancer research, 2004 - AACR
Previous studies have shown that BRCA1-related breast cancers are often high-grade
tumors that do not express estrogen receptors, HER2, p27Kip1, or cyclin D1, but do express …

CHARGE syndrome: the phenotypic spectrum of mutations in the CHD7 gene

…, L Vissers, AF Baas, L Kapusta… - Journal of medical …, 2006 - jmg.bmj.com
Background: CHARGE syndrome is a non-random clustering of congenital anomalies
including coloboma, heart defects, choanal atresia, retarded growth and development …

Pediatric pulmonary hypertension in the Netherlands: epidemiology and characterization during the period 1991 to 2005

…, M van Osch-Gevers, T Delhaas, L Kapusta… - Circulation, 2011 - Am Heart Assoc
Background—Incidence and prevalence rates for pediatric pulmonary hypertension (PH)
and pulmonary arterial hypertension (PAH) are unknown. This study describes the …

Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study

…, W Hui, L Lagae, MA Willemsen, L Kapusta… - The lancet …, 2012 - thelancet.com
Background Chemotherapy for the treatment of maternal cancers during pregnancy has
become more acceptable in the past decade; however, the effect of prenatal exposure to …

Loss of Cyclin-dependent Kinase Inhibitor p27Kip1 Is a Novel Prognostic Factor in Localized Human Prostate Adenocarcinoma

J Tsihlias, LR Kapusta, G DeBoer, I Morava-Protzner… - Cancer research, 1998 - AACR
Abstract p27Kip1 is a cyclin-dependent kinase inhibitor that negatively regulates cell
proliferation by mediating cell cycle arrest in G1. This study was undertaken to assess the …

Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case–control study in the northern Netherlands

IM van Beynum, L Kapusta, MK Bakker… - European heart …, 2010 - academic.oup.com
Aims To investigate the potentially protective of periconceptional folic acid use on the risk of
congenital heart defects (CHDs) relative to other non-folate related malformations. Methods …