Purpose: STATs activate transcription in response to numerous cytokines, controlling
proliferation, gene expression, and apoptosis. Aberrant activation of STAT proteins …

Although 1p/19q codeletions define “genetically favorable” oligodendrogliomas, eventual
tumor progression and patient death remain constant. Genetic testing is often performed at …

Cellular Src activity modulates cell migration, proliferation, and differentiation, and recent
reports suggest that individual members of the Src family may play specific roles in these …

Background The limited success of empirically designed treatment paradigms for patients
diagnosed with glioblastoma multiforme (GBM) emphasizes the need for rationally designed …

The NF-κB family mediates immune and inflammatory responses. In many cancers, NF-κB is
constitutively activated and induces the expression of genes that facilitate tumorigenesis …

Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells
suggest that sex hormones may play a role in the onset of primary brain tumors. However …

MicroRNAs (miRNAs) are non-coding RNAs that function as post-transcriptional regulators
of tumor suppressors and oncogenes. Single nucleotide polymorphisms (SNPs) in miRNAs …

Purpose There is growing evidence that circadian disruption may alter risk and
aggressiveness of cancer. We evaluated common genetic variants in the circadian gene …

Chemotherapeutic drugs such as the alkylating agent Temozolomide (TMZ), in addition to
reducing tumor mass, can also sensitize tumors to immune recognition by transient …

Validation of a recent finding linking a rare variant in TP53 to the risk of glioma, the most
common primary brain tumour, is reported here. This study genotyped the single nucleotide …