User profiles for "author:L A Cupples"
L Adrienne CupplesProfessor of Biostatistics Verified email at bu.edu Cited by 227113 |
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …
the world and has received considerable attention regarding health risks and benefits. We …
[HTML][HTML] The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
LA Cupples, HT Arruda, EJ Benjamin… - BMC medical …, 2007 - Springer
Abstract Background The Framingham Heart Study (FHS), founded in 1948 to examine the
epidemiology of cardiovascular disease, is among the most comprehensively characterized …
epidemiology of cardiovascular disease, is among the most comprehensively characterized …
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis
Objective.—To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …
Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures
The choice of a phenotype is critical for the study of a complex genetically regulated
process, such as aging. To date, most of the twin and family studies have focused on broad …
process, such as aging. To date, most of the twin and family studies have focused on broad …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease …
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease …
Variants in MTNR1B influence fasting glucose levels
To identify previously unknown genetic loci associated with fasting glucose concentrations,
we examined the leading association signals in ten genome-wide association scans …
we examined the leading association signals in ten genome-wide association scans …
[PDF][PDF] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …