User profiles for "author:L A Cupples"

L Adrienne Cupples

Professor of Biostatistics
Verified email at bu.edu
Cited by 227113

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

MC Cornelis, EM Byrne, T Esko, MA Nalls… - Molecular …, 2015 - nature.com
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

[HTML][HTML] The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

LA Cupples, HT Arruda, EJ Benjamin… - BMC medical …, 2007 - Springer
Abstract Background The Framingham Heart Study (FHS), founded in 1948 to examine the
epidemiology of cardiovascular disease, is among the most comprehensively characterized …

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis

LA Farrer, LA Cupples, JL Haines, B Hyman, WA Kukull… - Jama, 1997 - jamanetwork.com
Objective.—To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures

D Karasik, S Demissie, LA Cupples… - The Journals of …, 2005 - academic.oup.com
The choice of a phenotype is critical for the study of a complex genetically regulated
process, such as aging. To date, most of the twin and family studies have focused on broad …

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

BF Voight, GM Peloso, M Orho-Melander… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

BW Kunkle, B Grenier-Boley, R Sims, JC Bis… - Nature …, 2019 - nature.com
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Common variants at 30 loci contribute to polygenic dyslipidemia

S Kathiresan, CJ Willer, GM Peloso, S Demissie… - Nature …, 2009 - nature.com
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou… - Nature …, 2007 - nature.com
The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease …

Variants in MTNR1B influence fasting glucose levels

I Prokopenko, C Langenberg, JC Florez, R Saxena… - Nature …, 2009 - nature.com
To identify previously unknown genetic loci associated with fasting glucose concentrations,
we examined the leading association signals in ten genome-wide association scans …

[PDF][PDF] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

MV Holmes, CE Dale, L Zuccolo, RJ Silverwood, Y Guo… - Bmj, 2014 - bmj.com
Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …