Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis

C Dorard, A De Thonel, A Collura, L Marisa, M Svrcek… - Nature medicine, 2011 - nature.com
Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of
HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC) …

The balance between cytotoxic T-cell lymphocytes and immune checkpoint expression in the prognosis of colon tumors

L Marisa, M Svrcek, A Collura, E Becht… - JNCI: Journal of the …, 2018 - academic.oup.com
Background Immune checkpoint (ICK) expression might represent a surrogate measure of
tumor-infiltrating T cell (CTL) exhaustion and therefore be a more accurate prognostic …

A Simple Specific Pattern of Chromosomal Aberrations at Early Stages of Head and Neck Squamous Cell Carcinomas: PIK3CA but not p63 Gene as a …

R Redon, D Muller, K Caulee, K Wanherdrick… - Cancer research, 2001 - AACR
Low-grade head and neck squamous cell carcinomas without lymph node involvement or
distant metastasis (N0M0) were screened for chromosomal imbalances by comparative …

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy

A Collura, A Lagrange, M Svrcek, L Marisa, O Buhard… - Gastroenterology, 2014 - Elsevier
Background & Aims Patients with colorectal tumors with microsatellite instability (MSI) have
better prognoses than patients with tumors without MSI, but have a poor response to 5 …

HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer

O Buhard, A Lagrange, A Guilloux, C Colas… - Journal of medical …, 2016 - jmg.bmj.com
Background Every colorectal cancer (CRC) patient should be tested for microsatellite
instability (MSI, a marker for defective DNA mismatch repair) as a first screen for Lynch …

Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level

IL Jaabar, P Cornette, A Miche, K Wanherdrick… - Nanoscale, 2022 - pubs.rsc.org
The extracellular matrix (ECM) of articular cartilage is a three-dimensional network mainly
constituted of entangled collagen fibrils and interfibrillar aggrecan aggregates. During the …

Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases

M Svrcek, N El-Murr, K Wanherdrick, S Dumont… - …, 2013 - academic.oup.com
Microsatellite instability (MSI) due to mismatch repair (MMR) deficiency is reported in 5–10%
of colorectal cancers (CRCs) complicating inflammatory bowel diseases (IBD). The …

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling

S Gora, S Maouche, R Atout, K Wanherdrick… - The FASEB …, 2010 - Wiley Online Library
Secreted phospholipases A2 (sPLA2s) are present in atherosclerotic plaques and are now
considered novel attractive therapeutic targets and potential biomarkers as they contribute to …

Extracellular HSP110 skews macrophage polarization in colorectal cancer

K Berthenet, C Boudesco, A Collura, M Svrcek… - …, 2016 - Taylor & Francis
ABSTRACT HSP110 is induced by different stresses and, through its anti-apoptotic and
chaperoning properties, helps the cells to survive these adverse situations. In colon cancers …

[HTML][HTML] MiRNA Genes Constitute New Targets for Microsatellite Instability in Colorectal Cancer

N El-Murr, Z Abidi, K Wanherdrick, M Svrcek, MP Gaub… - PloS one, 2012 - journals.plos.org
Mismatch repair-deficient colorectal cancers (CRC) display widespread instability at DNA
microsatellite sequences (MSI). Although MSI has been reported to commonly occur at …