Skeletal abnormalities are an early and prominent feature of most mucopolysaccharide
(MPS) disorders, with the degree of skeletal involvement varying between and within MPS …

Abstract Mucopolysaccharidosis IVA (MPS IVA), also known as Morquio-Brailsford or
Morquio A syndrome, is a lysosomal storage disorder caused by a deficiency of the enzyme …

Background The most pronounced symptom in mucopolysaccharidosis type III (MPS III,
Sanfilippo Syndrome) is the severe neurocognitive deterioration of the central nervous …

Background Mucopolysaccharidosis VII (MPS VII) is an ultra-rare disease characterised by
the deficiency of β-glucuronidase (GUS). Patients' phenotypes vary from severe forms with …

Background There are no effective therapies for achondroplasia. An open-label study
suggested that vosoritide administration might increase growth velocity in children with …

Purpose Achondroplasia is caused by pathogenic variants in the fibroblast growth factor
receptor 3 gene that lead to impaired endochondral ossification. Vosoritide, an analog of C …

Purpose Females have a disproportionately high incidence of anterior cruciate ligament
(ACL) injuries compared with males in analogous sports. Although the pathogenesis of this …

Achondroplasia is the most common inherited disorder of bone growth (skeletal dysplasia).
Despite this fact, consistent and evidence‐based management approaches to recognized …

Study Design. In vitro biomechanical comparison of two methods of pedicle screw
placement in cadaveric thoracic spine vertebrae. Objective. Compare the biomechanical …

Background: Acute compartment syndrome has been widely reported in legs positioned in
the lithotomy position for prolonged general surgical, urologic, and gynecologic procedures …