A class of small, non-coding transcripts called microRNAs (miRNAs) that provide a crucial
and pervasive layer of post-transcriptional gene regulation has recently emerged and …

MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA
expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any …

There is an urgent need to find effective presymptomatic Alzheimer's disease (AD)
treatments that reduce the risk of AD symptoms or prevent them completely. It currently takes …

MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression
by targeting the mRNA of protein-coding genes for either cleavage or repression of …

The detailed protein composition of the paired helical filaments (PHF) that accumulate in
human neurons in aging and Alzheimer disease is unknown. However, the identity of certain …

Several hundred microRNAs (miRNAs) have recently been cloned from a wide range of
organisms across phylogeny. Despite the high degree of conservation of miRNAs, their …

Sponges are an ancient group of animals that diverged from other metazoans over 600
million years ago. Here we present the draft genome sequence of Amphimedon …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive accumulation in selected neurons of protein inclusions containing α-synuclein …

MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an
important role in many developmental processes. We report here that expression of …

To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …