User profiles for "author:Kenneth S Kosik"
Kenneth S. KosikUC Santa Barbara Verified email at lifesci.ucsb.edu Cited by 54773 |
The neuronal microRNA system
KS Kosik - Nature Reviews Neuroscience, 2006 - nature.com
A class of small, non-coding transcripts called microRNAs (miRNAs) that provide a crucial
and pervasive layer of post-transcriptional gene regulation has recently emerged and …
and pervasive layer of post-transcriptional gene regulation has recently emerged and …
[PDF][PDF] MicroRNAs potentiate neural development
SK Fineberg, KS Kosik, BL Davidson - Neuron, 2009 - cell.com
MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA
expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any …
expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any …
Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments
EM Reiman, J Langbaum, AS Fleisher… - Journal of …, 2011 - content.iospress.com
There is an urgent need to find effective presymptomatic Alzheimer's disease (AD)
treatments that reduce the risk of AD symptoms or prevent them completely. It currently takes …
treatments that reduce the risk of AD symptoms or prevent them completely. It currently takes …
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression
by targeting the mRNA of protein-coding genes for either cleavage or repression of …
by targeting the mRNA of protein-coding genes for either cleavage or repression of …
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
KS KoSIK, CL Joachim… - Proceedings of the …, 1986 - National Acad Sciences
The detailed protein composition of the paired helical filaments (PHF) that accumulate in
human neurons in aging and Alzheimer disease is unknown. However, the identity of certain …
human neurons in aging and Alzheimer disease is unknown. However, the identity of certain …
A microRNA array reveals extensive regulation of microRNAs during brain development
Several hundred microRNAs (miRNAs) have recently been cloned from a wide range of
organisms across phylogeny. Despite the high degree of conservation of miRNAs, their …
organisms across phylogeny. Despite the high degree of conservation of miRNAs, their …
[HTML][HTML] The Amphimedon queenslandica genome and the evolution of animal complexity
M Srivastava, O Simakov, J Chapman, B Fahey… - Nature, 2010 - nature.com
Sponges are an ancient group of animals that diverged from other metazoans over 600
million years ago. Here we present the draft genome sequence of Amphimedon …
million years ago. Here we present the draft genome sequence of Amphimedon …
Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive accumulation in selected neurons of protein inclusions containing α-synuclein …
progressive accumulation in selected neurons of protein inclusions containing α-synuclein …
[HTML][HTML] MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
N Xu, T Papagiannakopoulos, G Pan, JA Thomson… - Cell, 2009 - cell.com
MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an
important role in many developmental processes. We report here that expression of …
important role in many developmental processes. We report here that expression of …
[HTML][HTML] Tau PTM profiles identify patient heterogeneity and stages of Alzheimer's disease
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …