Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in
industrialized countries. Liver samples from morbidly obese patients (n= 45) with all stages …

Although Burkitt lymphomas and follicular lymphomas both have features of germinal center
B cells, they are biologically and clinically quite distinct. Here we performed whole-genome …

Background Genomic imprinting results from the resistance of germline epigenetic marks to
reprogramming in the early embryo for a small number of mammalian genes. Genetic …

Abstract The WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue notes
instances of Burkitt lymphoma/leukemia (BL) with IG-MYC rearrangement displaying a B-cell …

Background ADAMs (a disintegrin and metalloproteinase) have long been associated with
tumor progression. Recent findings indicate that members of the closely related ADAMTS …

Despite recent progress in molecular karyotyping and clinical sequencing the cause of
intellectual disability in a considerable subset of individuals affected by this phenotype …

Aim: To characterize the genotypic and phenotypic extent of multilocus imprinting
disturbances (MLID). Materials & methods: We analyzed 37 patients with imprinting …

Epigenetic mechanisms including DNA methylation are supposed to play a key role in fetal
development. Here we have investigated fetal DNA-methylation levels of 27,578 CpG loci in …

Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1
kinase inhibitors, resistance due to kinase alterations or to BCR‑ABL1 independent …

Deregulation of the epigenome is an important pathogenetic mechanism in acute
lymphoblastic leukemia (ALL) with lysine (K)‐specific methyltransferase 2A rearrangement …