Genetic diagnosis is recommended for all pheochromocytoma and paraganglioma (PPGL)
cases, as driver mutations are identified in approximately 80% of the cases. As the list of …

Background In the phase III OlympiAD trial, olaparib significantly increased progression-free
survival (PFS) compared with chemotherapy of physician's choice in patients with germline …

Importance Genetic testing of hereditary cancer using comprehensive gene panels can
identify patients with more than one pathogenic mutation in high and/or moderate-risk …

Approximately 10% of breast cancers are associated with the inheritance of a pathogenic
variant (PV) in one of the breast cancer susceptibility genes. Multiple breast cancer …

Rothmund-Thomson syndrome, a heterogeneous genodermatosis with autosomal recessive
hereditary pattern, is an uncommon cancer susceptibility genetic syndrome. To date, only …

Fanconi anemia (FA) patients display an exacerbated risk of oral squamous cell carcinoma
(OSCC) and oral potentially malignant lesions (OPMLs) at early ages. As patients have …

Purpose: PARP inhibitors (PARPi) induce synthetic lethality in homologous recombination
repair (HRR)-deficient tumors and are used to treat breast, ovarian, pancreatic, and prostate …

Background Recent population-based female breast cancer and prostate cancer polygenic
risk scores (PRS) have been developed. We assessed the associations of these PRS with …

The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains
unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) …

Most academic precision oncology programs have been designed to facilitate enrollment of
patients in early clinical trials with matched targeted agents. Over the last decade, major …