Variants within non-coding genomic regions can greatly affect disease. In recent years,
increasing focus has been given to these variants, and how they can alter regulatory …

Bacteria can clearly enhance their survival by expanding their genetic repertoire. However,
the tight packing of the bacterial genome and the fact that the most evolved species do not …

The identification of the whole set of protein interactions taking place in an organism is one
of the main tasks in genomics, proteomics and systems biology. One of the computational …

By exploiting three-dimensional structure comparison, which is more sensitive than
conventional sequence-based methods for detecting remote homology, we have identified a …

We present the structural annotation of 56 different bacterial species based on the
assignment of genes to 816 evolutionary superfamilies in the CATH domain structure …

Biofilm formation is a strategy of many bacterial species to adapt to a variety of stresses and
has become a part of infections, contaminations, or beneficial interactions. In this study, we …

Network and systemic approaches to studying human pathologies are helping us to gain
insight into the molecular mechanisms of and potential therapeutic interventions for human …

Protein domains mediate drug-protein interactions and this principle can guide the design of
multi-target drugs ie polypharmacology. In this study, we associate multi-target drugs with …

Genetic and molecular analysis of rare disease is made difficult by the small numbers of
affected patients. Phenotypic comorbidity analysis can help rectify this by combining …

Background Protein function prediction remains a key challenge. Domain composition
affects protein function. Here we present DomFun, a Ruby gem that uses associations …