Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome.
RM Peek Jr, SA Thompson, JP Donahue… - Proceedings of the …, 1998 - europepmc.org
Most persons infected with Helicobacter pylori strains that produce vacuolating cytotoxin and
possess cytotoxin-associated gene A (cagA) genotype nonetheless remain asymptomatic …
possess cytotoxin-associated gene A (cagA) genotype nonetheless remain asymptomatic …
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study
DW Haas, LM Smeaton, RW Shafer… - The Journal of …, 2005 - academic.oup.com
Background Efavirenz and nelfinavir are metabolized by cytochrome P-450 (CYP) 2B6 and
CYP2C19, respectively, with some involvement by CYP3A. Nelfinavir is a substrate for P …
CYP2C19, respectively, with some involvement by CYP3A. Nelfinavir is a substrate for P …
Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB …
TR Torgerson, AD Colosia, JP Donahue… - The Journal of …, 1998 - journals.aai.org
Activation of T lymphocytes by Ags or cytokines results in translocation of the transcription
factors NF-κB, AP-1, NFAT, and STAT from the cytoplasm into the nucleus. The first step in …
factors NF-κB, AP-1, NFAT, and STAT from the cytoplasm into the nucleus. The first step in …
Genetic engineering of proteins with cell membrane permeability
M Rojas, JP Donahue, Z Tan, YZ Lin - Nature biotechnology, 1998 - nature.com
The discovery of methods for generating proteins with inherent cell membrane-translocating
activity will expand our ability to study and manipulate various intracellular processes in …
activity will expand our ability to study and manipulate various intracellular processes in …
[HTML][HTML] Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
RG De Bruin, L Shiue, J Prins, HC De Boer… - Nature …, 2016 - nature.com
A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to
sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli …
sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli …
Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori
JP Donahue, DA Israel, RM Peek Jr… - Molecular …, 2000 - Wiley Online Library
Helicobacter pylori strains demonstrate substantial variability in the efficiency of
transformation by plasmids from Escherichia coli, and many strains are completely resistant …
transformation by plasmids from Escherichia coli, and many strains are completely resistant …
Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity
MD Ritchie, DW Haas, AA Motsinger… - Clinical Infectious …, 2006 - academic.oup.com
This nested case-control study examined relationships between MDR1, CYP2B6, and
CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either efavirenz-or …
CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either efavirenz-or …
[HTML][HTML] The HIV-1 Vif PPLP motif is necessary for human APOBEC3G binding and degradation
JP Donahue, ML Vetter, NA Mukhtar, TD Richard - Virology, 2008 - Elsevier
The HIV-1 virion infectivity factor (Vif) is required during viral replication to inactivate the host
cell anti-viral factor, APOBEC3G (A3G). Vif binds A3G and a Cullin5-ElonginBC E3 ubiquitin …
cell anti-viral factor, APOBEC3G (A3G). Vif binds A3G and a Cullin5-ElonginBC E3 ubiquitin …
Attenuation control of pyrBI operon expression in Escherichia coli K-12.
CL Turnbough Jr, KL Hicks… - Proceedings of the …, 1983 - National Acad Sciences
The pyrBI operon of Escherichia coli K-12 encodes the subunits of the pyrimidine
biosynthetic enzyme aspartate transcarbamylase (carbamoylphosphate: L-aspartate …
biosynthetic enzyme aspartate transcarbamylase (carbamoylphosphate: L-aspartate …
Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study
Objective For the HIV-1 reverse transcriptase inhibitor efavirenz, variant drug transporter
gene ABCB1 may predict virologic response but not plasma efavirenz exposure …
gene ABCB1 may predict virologic response but not plasma efavirenz exposure …