We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the
deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation …

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine,. Patients with leukaemia can be identified using machine …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Lung cancer remains one of the leading causes of cancer-related death in developed
countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions …

Colletotrichum species are fungal pathogens that devastate crop plants worldwide. Host
infection involves the differentiation of specialized cell types that are associated with …

Many" complex" human diseases, which involve multiple genetic and environmental
determinants, have increased in incidence during the past 2 decades. During the same time …

Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system.
Roughly half of these tumours regress spontaneously or are cured by limited therapy. By …

Pathologic thrombosis is a major cause of mortality. Hemolytic-uremic syndrome (HUS)
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …