Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
[HTML][HTML] Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis …
FM Blows, KE Driver, MK Schmidt, A Broeks… - PLoS …, 2010 - journals.plos.org
Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …
subtypes that are biologically distinct and behave differently. The aim of this study was to …
Biobanks and personalized medicine
JE Olson, SJ Bielinski, E Ryu, EM Winkler… - Clinical …, 2014 - Wiley Online Library
We provide a mini‐review of how biobanks can support clinical genetics in the era of
personalized medicine. We discuss types of biobanks, including disease specific and …
personalized medicine. We discuss types of biobanks, including disease specific and …
Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study
AR Folsom, LH Kushi, KE Anderson… - Archives of internal …, 2000 - jamanetwork.com
Background Recent clinical guidelines on the health risks of obesity use body mass index
(BMI; calculated as weight in kilograms divided by the square of height in meters) and waist …
(BMI; calculated as weight in kilograms divided by the square of height in meters) and waist …
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
XR Yang, J Chang-Claude, EL Goode… - Journal of the …, 2011 - academic.oup.com
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …
A common coding variant in CASP8 is associated with breast cancer risk
A Cox, AM Dunning, M Garcia-Closas… - Nature …, 2007 - nature.com
Abstract The Breast Cancer Association Consortium (BCAC) has been established to
conduct combined case-control analyses with augmented statistical power to try to confirm …
conduct combined case-control analyses with augmented statistical power to try to confirm …
[HTML][HTML] Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer
Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the …
susceptibility gene panels for germline genetic testing of patients. We assessed the …
Prediction of breast cancer risk based on profiling with common genetic variants
N Mavaddat, PDP Pharoah… - Journal of the …, 2015 - academic.oup.com
Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …
combined to identify women at different levels of breast cancer risk. Such stratification could …
[HTML][HTML] A population-based study of genes previously implicated in breast cancer
C Hu, SN Hart, R Gnanaolivu, H Huang… - … England Journal of …, 2021 - Mass Medical Soc
Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …