Transfer RNA modifications: nature's combinatorial chemistry playground
JE Jackman, JD Alfonzo - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …
differentially affect a tRNA's structure and function. Although modifications affecting the …
Antibacterial and anti-inflammatory agents that target endotoxin
TJO Wyckoff, CRH Raetz, JE Jackman - Trends in microbiology, 1998 - cell.com
Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of
lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new …
lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new …
Diversity in mechanism and function of tRNA methyltransferases
WE Swinehart, JE Jackman - RNA biology, 2015 - Taylor & Francis
tRNA molecules undergo extensive post-transcriptional processing to generate the mature
functional tRNA species that are essential for translation in all organisms. These processing …
functional tRNA species that are essential for translation in all organisms. These processing …
Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH …
T Ogura, K Inoue, T Tatsuta, T Suzaki… - Molecular …, 1999 - Wiley Online Library
The suppressor mutation, named sfhC21, that allows Escherichia coli ftsH null mutant cells
to survive was found to be an allele of fabZ encoding R‐3‐hydroxyacyl‐ACP dehydrase …
to survive was found to be an allele of fabZ encoding R‐3‐hydroxyacyl‐ACP dehydrase …
Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9
Methylation of tRNA at the N-1 position of guanosine to form m1G occurs widely in nature. It
occurs at position 37 in tRNAs from all three kingdoms, and the methyltransferase that …
occurs at position 37 in tRNAs from all three kingdoms, and the methyltransferase that …
[HTML][HTML] Antibacterial Agents That Target Lipid A Biosynthesis in Gram-negative Bacteria: Inhibition of diverse UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine …
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) catalyzes the
second step in the biosynthesis of lipid A, a unique amphiphilic molecule found in the outer …
second step in the biosynthesis of lipid A, a unique amphiphilic molecule found in the outer …
tRNAHis maturation: An essential yeast protein catalyzes addition of a guanine nucleotide to the 5′ end of tRNAHis
All tRNAHis molecules are unusual in having an extra 5′ GMP residue (G-1) that, in
eukaryotes, is added after transcription and RNase P cleavage. Incorporation of this G-1 …
eukaryotes, is added after transcription and RNase P cleavage. Incorporation of this G-1 …
UDP-3-O-(R-3-Hydroxymyristoyl)-N-acetylglucosamine Deacetylase of Escherichia coli Is a Zinc Metalloenzyme
JE Jackman, CRH Raetz, CA Fierke - Biochemistry, 1999 - ACS Publications
The enzyme UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase (LpxC) catalyzes the
committed step in the biosynthesis of lipid A and is therefore a potential antibiotic target …
committed step in the biosynthesis of lipid A and is therefore a potential antibiotic target …
TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly
D Gillis, A Krishnamohan, B Yaacov, A Shaag… - Journal of medical …, 2014 - jmg.bmj.com
Background Trm10 is a tRNA m1G9 methyltransferase, which in yeast modifies 12 different
tRNA species, yet is considered non-essential for viability under standard growth conditions …
tRNA species, yet is considered non-essential for viability under standard growth conditions …
Inhibition of the Antibacterial Target UDP-(3-O-acyl)-N-acetylglucosamine Deacetylase (LpxC): Isoxazoline Zinc Amidase Inhibitors Bearing Diverse Metal Binding …
MC Pirrung, LN Tumey, CRH Raetz… - Journal of medicinal …, 2002 - ACS Publications
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase (LpxC) is a zinc amidase that
catalyzes the second step of lipid A biosynthesis in Gram negative bacteria. Known …
catalyzes the second step of lipid A biosynthesis in Gram negative bacteria. Known …