Germ-line msh6 Mutations in Colorectal Cancer Families
RD Kolodner, JD Tytell, JL Schmeits, MF Kane… - Cancer Research, 1999 - AACR
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is due primarily to inherited
mutations in two mismatch repair genes, MSH2 and MLH1, whereas germ-line mutations in …
mutations in two mismatch repair genes, MSH2 and MLH1, whereas germ-line mutations in …
One-megabase sequence analysis of the human immunoglobulin lambda gene locus.
K Kawasaki, S Minoshima, E Nakato… - Genome …, 1997 - genome.cshlp.org
A total of 1,025,415 bases of nucleotide sequence, including the entire human
immunoglobulin lambda gene locus has been determined. This is the largest contiguous …
immunoglobulin lambda gene locus has been determined. This is the largest contiguous …
Discovery of tropifexor (LJN452), a highly potent non-bile acid FXR agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH)
DC Tully, PV Rucker, D Chianelli, J Williams, A Vidal… - 2017 - ACS Publications
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile
acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases …
acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases …
Evaluation of Microsatellite Instability and Immunohistochemistry for the Prediction of Germ-Line MSH2 and MLH1 Mutations in Hereditary Nonpolyposis Colon …
SS Wahlberg, J Schmeits, G Thomas, M Loda, J Garber… - Cancer research, 2002 - AACR
Forty-eight hereditary nonpolyposis colorectal carcinoma (HNPCC) familiesfor which a
tumor sample was available were evaluated for the presence of germ-line mutations in …
tumor sample was available were evaluated for the presence of germ-line mutations in …
Nidufexor (LMB763), a novel FXR modulator for the treatment of nonalcoholic steatohepatitis
D Chianelli, PV Rucker, J Roland… - Journal of medicinal …, 2020 - ACS Publications
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for
the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects …
the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects …
[PDF][PDF] Tropifexor‐mediated abrogation of steatohepatitis and fibrosis is associated with the antioxidative gene expression profile in rodents
Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic
mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist …
mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist …
Structure−Function Relationships in Anabaena Ferredoxin: Correlations between X-ray Crystal Structures, Reduction Potentials, and Rate Constants of Electron Transfer to Ferredoxin …
JK Hurley, AM Weber-Main, MT Stankovich… - Biochemistry, 1997 - ACS Publications
A combination of structural, thermodynamic, and transient kinetic data on wild-type and
mutant Anabaena vegetative cell ferredoxins has been used to investigate the nature of the …
mutant Anabaena vegetative cell ferredoxins has been used to investigate the nature of the …
Mononucleotide microsatellite instability and germlineMSH6 mutation analysis in early onset colorectal cancer
L Verma, MF Kane, C Brassett, J Schmeits… - Journal of medical …, 1999 - jmg.bmj.com
Germline mutations in the MSH2 and MLH1 mismatch repair genes account for most cases
of hereditary non-polyposis colon cancer syndrome (HNPCC). In addition, germline MSH2 …
of hereditary non-polyposis colon cancer syndrome (HNPCC). In addition, germline MSH2 …
[PDF][PDF] Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
A Datta, JL Schmeits, NS Amin, PJ Lau, K Myung… - Molecular cell, 2000 - cell.com
The Saccharomyces cerevisiae DNA polymerase δ proofreading exonuclease-defective
mutation pol3-01 is known to cause high rates of accumulating mutations. The pol3-01 …
mutation pol3-01 is known to cause high rates of accumulating mutations. The pol3-01 …
An endomembrane-localized small heat-shock protein from Arabidopsis thaliana.
KW Helm, J Schmeits, E Vierling - Plant physiology, 1995 - ncbi.nlm.nih.gov
Nearly a11 eukaryotes respond to high-temperature stress by producing HSPs, which are
required for survival at high temperatures (Parsell and Lindquist, 1993). Of the major gene …
required for survival at high temperatures (Parsell and Lindquist, 1993). Of the major gene …