Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers

RS van der Post, IP Vogelaar, F Carneiro… - Journal of medical …, 2015 - jmg.bmj.com
Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

Hereditary diffuse gastric cancer: updated clinical practice guidelines

VR Blair, M McLeod, F Carneiro, DG Coit… - The Lancet …, 2020 - thelancet.com
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

[PDF][PDF] The human tumor atlas network: charting tumor transitions across space and time at single-cell resolution

O Rozenblatt-Rosen, A Regev, P Oberdoerffer, T Nawy… - Cell, 2020 - cell.com
Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic …

Homologous recombination deficiency (HRD) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer

ML Telli, KM Timms, J Reid, B Hennessy, GB Mills… - Clinical cancer …, 2016 - AACR
Abstract Purpose: BRCA1/2-mutated and some sporadic triple-negative breast cancers
(TNBC) have DNA repair defects and are sensitive to DNA-damaging therapeutics …

[HTML][HTML] Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines

AA Powell, AAH Talasaz, H Zhang, MA Coram… - PloS one, 2012 - journals.plos.org
Background To improve cancer therapy, it is critical to target metastasizing cells. Circulating
tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may …

[PDF][PDF] American Society of Clinical Oncology policy statement update: genetic and genomic testing for cancer susceptibility

ME Robson, AR Bradbury, B Arun… - Journal of Clinical …, 2015 - cibic.com.ar
ABSTRACT The American Society of Clinical Oncology (ASCO) has long affirmed that the
recognition and management of individuals with an inherited susceptibility to cancer are …

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

BJ Hwang, JM Ford, PC Hanawalt… - Proceedings of the …, 1999 - National Acad Sciences
In human cells, efficient global genomic repair of DNA damage induced by ultraviolet
radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 …

p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/orgadd45 Genes

ML Smith, JM Ford, MC Hollander… - … and cellular biology, 2000 - Am Soc Microbiol
Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair
(NER), the pathway for repair of UV-induced DNA damage. The global genomic repair …

Clinical interpretation and implications of whole-genome sequencing

FE Dewey, ME Grove, C Pan, BA Goldstein… - Jama, 2014 - jamanetwork.com
Importance Whole-genome sequencing (WGS) is increasingly applied in clinical medicine
and is expected to uncover clinically significant findings regardless of sequencing indication …

[HTML][HTML] Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment

AW Kurian, EE Hare, MA Mills… - Journal of clinical …, 2014 - ncbi.nlm.nih.gov
Purpose Multiple-gene sequencing is entering practice, but its clinical value is unknown. We
evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk …