Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

We conducted a genome-wide association study testing single nucleotide polymorphisms
(SNPs) and copy number variants (CNVs) for association with early-onset myocardial …

We sequenced all protein-coding regions of the genome (the “exome”) in two family
members with combined hypolipidemia, marked by extremely low plasma levels of low …

Context Plasma levels of C-reactive protein (CRP) are independently associated with risk of
coronary heart disease, but whether CRP is causally associated with coronary heart disease …

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans
has been accumulating over the last decade, in particular a large number of loci derived …

Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme
obesity [eg body mass index (BMI)≥ 40 kg/m2], but their contribution to common obesity …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS or SACS) is an early
onset neurodegenerative disease with high prevalence (carrier frequency 1/22) in the …

Background—Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of
coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 …

OBJECTIVE—A genome-wide association study conducted by the Wellcome Trust Case
Control Consortium recently associated single nucleotide polymorphisms (SNPs) in the FTO …