In the developing brain, many transcription factors are expressed in complex patterns and
dynamics, and drive the differentiation of many classes of neurons. How does the spatio …

The immunoglobulin superfamily is a group of proteins, each made of one or several
domains sharing key structural features with either the variable (V) or the constant (C) …

NCAM is a large family of structurally closely related proteins with cell-cell adhesive
properties and a temporo-spatially regulated expression throughout development. This …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

Recent evidence suggests that specific families of homeo-domain transcription factors
control the generation and survival of distinct neuronal types. We had previously char …

Vertebrates express scores of bHLH proteins during neural development. Earlier studies
inspired by the established role of “proneural” genes in fly neurogenesis, as well as by the …

We report that the afferent relays of visceral (cardiovascular, digestive and respiratory)
reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural …

Multipotent precursors able to generate neurons, astrocytes, and oligodendrocytes have
previously been isolated from human brain embryos and recently from neurogenic regions …

Mash1, a mammalian homologue of the Drosophila proneural genes of the achaete-scute
complex, is transiently expressed throughout the developing peripheral autonomic nervous …

Central congenital hypoventilation syndrome is caused by mutations of the gene that
encodes the transcription factor Phox2b. The syndrome is characterized by a severe form of …