T HE 5q-SYNDROME was first described by Van den Berghe et al'in 1974 in three patients
with refractory anemia and an interstitial deletion of the long arm of chromosome 5. This …

The past decade has seen an explosion of interest in the epigenetics of cancer, with an
increasing understanding that this form of genomic modification plays a critical role in …

Circulating nucleic acids have been shown to have potential as non‐invasive diagnostic
markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility …

We have developed a real-time quantitative PCR assay to measure the concentration of fetal
DNA in maternal plasma and serum. Our results show that fetal DNA is present in high …

Background Myelodysplastic syndromes are a diverse and common group of chronic
hematologic cancers. The identification of new genetic lesions could facilitate new …

The 5q− syndrome is the most distinct of all the myelodysplastic syndromes with a clear
genotype/phenotype relationship. The significant progress made during recent years has …

Background The potential use of plasma and serum for molecular diagnosis has generated
interest. Tumour DNA has been found in the plasma and serum of cancer patients, and …

Background The ability to determine fetal RhD status noninvasively is useful in the treatment
of RhD-sensitized pregnant women whose partners are heterozygous for the RhD gene. The …

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core
component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS) …

Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly
40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal …