Expression profiling using cDNA microarrays

DJ Duggan, M Bittner, Y Chen, P Meltzer, JM Trent - Nature genetics, 1999 - nature.com
Abstract cDNA microarrays are capable of profiling gene expression patterns of tens of
thousands of genes in a single experiment. DNA targets, in the form of 3 expressed …

Toward precision medicine in glioblastoma: the promise and the challenges

MD Prados, SA Byron, NL Tran, JJ Phillips… - Neuro …, 2015 - academic.oup.com
Integrated sequencing strategies have provided a broader understanding of the genomic
landscape and molecular classifications of multiple cancer types and have identified various …

Heterogeneity of genetic alterations in prostate cancer: evidence of the complex nature of the disease

V Nwosu, J Carpten, JM Trent… - Human molecular …, 2001 - academic.oup.com
Prostate cancer is a complex, multifactorial disease with genetic and environmental factors
involved in its etiology. The search for genetic determinants involved in the disease has …

[HTML][HTML] Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

FS Leach, NC Nicolaides, N Papadopoulos, B Liu… - Cell, 1993 - cell.com
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …

The transcriptional program in the response of human fibroblasts to serum

VR Iyer, MB Eisen, DT Ross, G Schuler, T Moore… - science, 1999 - science.org
The temporal program of gene expression during a model physiological response of human
cells, the response of fibroblasts to serum, was explored with a complementary DNA …

Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry

AJ Maniotis, R Folberg, A Hess, EA Seftor… - The American journal of …, 1999 - Elsevier
Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous
melanomas generally lack evidence of significant necrosis and contain patterned networks …

Use of a cDNA microarray to analyse gene expression

J DeRisi, L Penland, ML Bittner, PS Meltzer, M Ray… - Nat. genet, 1996 - nature.com
The development and progression of cancer1–3 and the experimental reversal of
tumorigenicity4, 5 are accompanied by complex changes in patterns of gene expression …

High frequency of BRAF mutations in nevi

PM Pollock, UL Harper, KS Hansen, LM Yudt, M Stark… - Nature …, 2003 - nature.com
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog
B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected …

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

SL Anzick, J Kononen, RL Walker, DO Azorsa… - Science, 1997 - science.org
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with
steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of …

WAF1, a potential mediator of p53 tumor suppression

WS El-Deiry, T Tokino, VE Velculescu, DB Levy… - Cell, 1993 - cell.com
The ability of~ 53 to activate transcription from specific sequences suggests that genes
induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive …