Abnormal CAG expansions in the IT-15 gene are associated with Huntington disease (HD).
In the diagnostic setting it is necessary to define the limits of the CAG size ranges on normal …

The molecular analysis of a specific CAG repeat sequence in the Huntington's disease gene
in 440 Huntington's disease patients and 360 normal controls reveals a range of 30–70 …

Nonsyndromic X-linked mental retardation (MRX) syndromes are clinically homogeneous
but genetically heterogeneous disorders, whose genetic bases are largely unknown …

A clinical and molecular analysis of 439 individuals affected with myotonic dystrophy, from
101 kindreds, has shown that the size of the unstable CTG repeat detected in nearly all …

Background: Disruption of normal mechanisms for cell cycle regulation is important in
carcinogenesis. SAK and PLK are members of the polo family of serine threonine kinases …

Polo-like kinases in yeast, flies, and mammals regulate key events in mitosis. Such events
include spindle formation at G2/M, the anaphase-promoting complex (APC) at the exit from …

Dentatorubral and pallidoluysian atrophy (DRPLA) is an autosomal dominant disorder that
clinically overlaps with Huntington's disease (HD) and manifests combinations of chorea …

Friedreich ataxia is an autosomal recessive disorder caused by mutations in the FRDA gene
that encodes a 210‐amino acid protein called frataxin. An expansion of a GAA trinucleotide …

Transforming growth factor (TGF)-β1 is associated with tumor progression and resistance to
chemotherapy in established cancers, as well as host immune suppression. Here, we show …

Management of septic pulmonary embolism now suggests a predictability of the clinical
course which often allows an early decision regarding the need for definitive thoracotomy …