Genome instability is a feature of cancer cells, transcription being an important source of
DNA damage. This is in large part associated with R-loops, which hamper replication …

The hepatitis C virus (HCV) is a globally prevalent infectious pathogen. As many as 80% of
people infected with HCV do not control the virus and develop a chronic infection. Response …

Purpose The prevalence of chronic non-communicable diseases (NCDs) is increasing
worldwide. NCDs are the leading cause of both morbidity and mortality, and it is estimated …

Background Heritability estimates have revealed an important contribution of SNP variants
for most common traits; however, SNP analysis by single-trait genome-wide association …

Multimorbidity is an emerging topic in public health policy because of its increasing
prevalence and socio-economic impact. However, the age-and gender-dependent trends of …

Genome-wide association studies have identified thousands of loci associated with common
diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic …

Background Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder
characterised by the development of multiple schwannomas, especially on vestibular …

Objective: Nonalcoholic fatty liver disease (NAFLD), insulin resistance and liver fibrosis are
prevalent in individuals co-infected with HIV type 1 (HIV-1)/hepatitis C virus (HCV), even …

The detection of family relationships in genetic databases is of interest in various scientific
disciplines such as genetic epidemiology, population and conservation genetics, forensic …

Abstract Analysis of RNA sequencing (RNA-seq) data from related individuals is widely used
in clinical and molecular genetics studies. Prediction of kinship from RNA-seq data would be …