Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Genome-wide association studies (GWAS) have revealed that different diseases share
susceptibility variants. Twelve single-nucleotide polymorphisms (SNPs) previously …

Inflammation in carotid atherosclerotic plaque is linked to plaque rupture and
cerebrovascular accidents. The balance between pro-and anti-inflammatory mediators …

Background and aim Several studies have highlighted the association of the 12q13. 3–
12q14. 1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple …

ABSTRACT Interleukin‐12 (IL‐12) and the more recently discovered IL‐23 and IL‐27
constitute a unique family of structurally related, heterodimeric cytokines that regulate cell …

Objectives The mechanism by which atheroma plaque becomes unstable is not completely
understood to date but analysis of differentially expressed genes in stable versus unstable …

Cardiovascular disease, the leading cause of mortality worldwide, is primarily caused by
atherosclerosis, which is characterized by lipid and inflammatory cell accumulation in blood …

Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been
associated with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic …

Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque
development. Although the precise mechanisms involved in plaque destabilization are not …

The quality control mechanisms directing the folding of cytokines in the endoplasmic
reticulum (ER) are poorly understood. We have investigated ER chaperone usage by the …