There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

Arginine, a semi‐essential amino acid in humans, is critical for the growth of human cancers,
particularly those marked by de novo chemoresistance and a poor clinical outcome. In …

Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …

Background Poly (ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian
carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 …

Background The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the
role that platelets play in abetting cancer growth are unclear. Methods We analyzed clinical …

The nuclear factor κB (NF-κB) signaling pathway is important in cancer-related inflammation
and malignant progression. Here, we describe a new role for NF-κB in cancer in maintaining …

Purpose: To conduct a phase I clinical trial with a second-generation oncolytic herpes
simplex virus (HSV) expressing granulocyte macrophage colony-stimulating factor (Onco …

Purpose: We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in
ovarian cancer via abrogation of a tumor-promoting cytokine network. Experimental Design …

The genomic complexity of profound copy number aberrations has prevented effective
molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy …