Abstract Checkpoint kinase 2 (CHEK2, Chk2) emerges as an important signal transducer of
cellular responses to DNA damage and a candidate tumor suppressor whose defects …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …

Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …

Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to
breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …