The CHEK2 gene and inherited breast cancer susceptibility
H Nevanlinna, J Bartek - Oncogene, 2006 - nature.com
Abstract Checkpoint kinase 2 (CHEK2, Chk2) emerges as an important signal transducer of
cellular responses to DNA damage and a candidate tumor suppressor whose defects …
cellular responses to DNA damage and a candidate tumor suppressor whose defects …
[PDF][PDF] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined …
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context …
but the average magnitude of these risks is uncertain and may depend on the context …
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
K Michailidou, P Hall, A Gonzalez-Neira… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …
been identified as associated with susceptibility to breast cancer, and these account for∼ …
[HTML][HTML] Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis …
FM Blows, KE Driver, MK Schmidt, A Broeks… - PLoS …, 2010 - journals.plos.org
Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …
subtypes that are biologically distinct and behave differently. The aim of this study was to …
[HTML][HTML] Breast-Cancer Risk in Families with Mutations in PALB2
AC Antoniou, S Casadei, T Heikkinen… - … England Journal of …, 2014 - Mass Medical Soc
Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
P Bouwman, A Aly, JM Escandell, M Pieterse… - Nature structural & …, 2010 - nature.com
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to
breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a …
breast and ovarian cancer. BRCA1-mutated tumors show genomic instability, mainly as a …
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
XR Yang, J Chang-Claude, EL Goode… - Journal of the …, 2011 - academic.oup.com
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …
[HTML][HTML] Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer
Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the …
susceptibility gene panels for germline genetic testing of patients. We assessed the …
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 …
N Mavaddat, D Barrowdale, IL Andrulis… - … Biomarkers & Prevention, 2012 - AACR
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …