User profiles for "author:Helen Toledano"
Helen ToledanoConsultant Pediatric Oncologist, Schneider Children's Medical Center, Israel Verified email at clalit.org.il Cited by 3968 |
[PDF][PDF] Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups
Ependymal tumors across age groups are currently classified and graded solely by
histopathology. It is, however, commonly accepted that this classification scheme has limited …
histopathology. It is, however, commonly accepted that this classification scheme has limited …
[PDF][PDF] Comprehensive analysis of hypermutation in human cancer
We present an extensive assessment of mutation burden through sequencing analysis of>
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …
[PDF][PDF] Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors
J Torchia, B Golbourn, S Feng, KC Ho, P Sin-Chan… - Cancer cell, 2016 - cell.com
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms …
transcriptional subtypes with different clinical outcomes; however, the mechanisms …
SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis
M Hasselblatt, I Nagel, F Oyen, K Bartelheim… - Acta …, 2014 - Springer
Martin Hasselblatt· Inga Nagel· Florian Oyen· Kerstin Bartelheim· Robert B. Russell· Ulrich
Schüller· Reimar Junckerstorff· Marc Rosenblum· Ali H. Alassiri· Sabrina Rossi· Irene …
Schüller· Reimar Junckerstorff· Marc Rosenblum· Ali H. Alassiri· Sabrina Rossi· Irene …
Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …
[HTML][HTML] The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
LB Kilburn, DA Khuong-Quang, JR Hansford, D Landi… - Nature medicine, 2024 - nature.com
BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade
glioma (pLGG). Arm 1 (n= 77) of the ongoing phase 2 FIREFLY-1 (PNOC026) trial …
glioma (pLGG). Arm 1 (n= 77) of the ongoing phase 2 FIREFLY-1 (PNOC026) trial …
Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis
Background Childhood CNS primitive neuro-ectodermal brain tumours (PNETs) are very
aggressive brain tumours for which the molecular features and best treatment approaches …
aggressive brain tumours for which the molecular features and best treatment approaches …
[HTML][HTML] CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity
T Spence, P Sin-Chan, D Picard, M Barszczyk… - Acta …, 2014 - Springer
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been
linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising …
linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising …
Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor
outcomes with current chemoradiotherapy strategies. Our aim was to study the role of …
outcomes with current chemoradiotherapy strategies. Our aim was to study the role of …
[HTML][HTML] Survival benefit for individuals with constitutional mismatch repair deficiency undergoing surveillance
PURPOSE Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer
predisposition syndrome characterized by early-onset synchronous and metachronous …
predisposition syndrome characterized by early-onset synchronous and metachronous …