User profiles for "author:Helen Toledano"

Helen Toledano

Consultant Pediatric Oncologist, Schneider Children's Medical Center, Israel
Verified email at clalit.org.il
Cited by 3968

[PDF][PDF] Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups

KW Pajtler, H Witt, M Sill, DTW Jones, V Hovestadt… - Cancer cell, 2015 - cell.com
Ependymal tumors across age groups are currently classified and graded solely by
histopathology. It is, however, commonly accepted that this classification scheme has limited …

[PDF][PDF] Comprehensive analysis of hypermutation in human cancer

BB Campbell, N Light, D Fabrizio, M Zatzman, F Fuligni… - Cell, 2017 - cell.com
We present an extensive assessment of mutation burden through sequencing analysis of>
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …

[PDF][PDF] Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors

J Torchia, B Golbourn, S Feng, KC Ho, P Sin-Chan… - Cancer cell, 2016 - cell.com
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms …

SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis

M Hasselblatt, I Nagel, F Oyen, K Bartelheim… - Acta …, 2014 - Springer
Martin Hasselblatt· Inga Nagel· Florian Oyen· Kerstin Bartelheim· Robert B. Russell· Ulrich
Schüller· Reimar Junckerstorff· Marc Rosenblum· Ali H. Alassiri· Sabrina Rossi· Irene …

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis

J Torchia, D Picard, L Lafay-Cousin… - The lancet …, 2015 - thelancet.com
Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …

[HTML][HTML] The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

LB Kilburn, DA Khuong-Quang, JR Hansford, D Landi… - Nature medicine, 2024 - nature.com
BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade
glioma (pLGG). Arm 1 (n= 77) of the ongoing phase 2 FIREFLY-1 (PNOC026) trial …

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

D Picard, S Miller, CE Hawkins, E Bouffet… - The lancet …, 2012 - thelancet.com
Background Childhood CNS primitive neuro-ectodermal brain tumours (PNETs) are very
aggressive brain tumours for which the molecular features and best treatment approaches …

[HTML][HTML] CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

T Spence, P Sin-Chan, D Picard, M Barszczyk… - Acta …, 2014 - Springer
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been
linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising …

Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition

L Nobre, M Zapotocky, V Ramaswamy, S Ryall… - JCO precision …, 2020 - ascopubs.org
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor
outcomes with current chemoradiotherapy strategies. Our aim was to study the role of …

[HTML][HTML] Survival benefit for individuals with constitutional mismatch repair deficiency undergoing surveillance

C Durno, AB Ercan, V Bianchi, M Edwards… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
PURPOSE Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer
predisposition syndrome characterized by early-onset synchronous and metachronous …