The α—β tubulin heterodimer is the subunit from which microtubules are assembled. The
pathway leading to correctly folded α-and β-tubulins is unusually complex: it involves cycles …

The genetic causes of malformations of cortical development (MCD) remain largely
unknown. Here we report the discovery of multiple pathogenic missense mutations in …

The development of the mammalian brain is dependent on extensive neuronal migration.
Mutations in mice and humans that affect neuronal migration result in abnormal lamination …

Polymicrogyria is a relatively common but poorly understood defect of cortical development
characterized by numerous small gyri and a thick disorganized cortical plate lacking normal …

We describe the complete β-tubulin folding pathway. Folding intermediates produced via
ATP–dependent interaction with cytosolic chaperonin undergo a sequence of interactions …

Background Human reproduction depends on the fusion of a mature oocyte with a sperm
cell to form a fertilized egg. The genetic events that lead to the arrest of human oocyte …

The production of native α/β tubulin heterodimer in vitro depends on the action of cytosolic
chaperonin and several protein cofactors. We previously showed that four such cofactors …

The formation of the mammalian cortex requires the generation, migration, and
differentiation of neurons. The vital role that the microtubule cytoskeleton plays in these …

HE central dogma of molecular biology holds that proteins contain within their primary amino
acid sequence all the information that is required to dictate their three-dimensional structure …

Background TUBB8 is a primate-specific β-tubulin isotype whose expression is confined to
oocytes and the early embryo. We previously found that mutations in TUBB8 caused oocyte …