Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic and
environmental factors that results in degeneration of the nigrostriatal dopaminergic pathway …

Background A rare variant in the Triggering Receptor Expressed on Myeloid cells 2
(TREM2) gene has been reported to be a genetic risk factor for Alzheimer's disease by two …

Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has
implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is …

Summary Background Background The leucine-rich repeat kinase 2 gene (LRRK2)
harbours highly penetrant mutations that are linked to familial parkinsonism. However, the …

Objective: Eleven genetic loci have reached genome-wide significance in a recent meta-
analysis of genome-wide association studies in Parkinson disease (PD) based on …

See Gandhi and Plun-Favreau (doi: 10.1093/aww320) for a scientific commentary on this
article. It has been postulated that heterozygous mutations in recessive Parkinson's genes …

Background Two recent studies identified a mutation (p. Asp620Asn) in the vacuolar protein
sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease. Although …

Objectives In this case–control study, we investigated the association of the most common
COMT gene haplotypes (formed by single nucleotide polymorphisms (SNPs): rs6269: A> G; …

Objective: We studied the independent and joint effects of the genes encoding alpha‐
synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease …

Objective Mutations in the α-synuclein-encoding gene SNCA are considered as a rare
cause of Parkinson's disease (PD). Our objective was to examine the frequency of the SNCA …