Revisiting genome wide association studies (GWAS) in coeliac disease: replication study in Spanish population and expression analysis of candidate genes

L Plaza-Izurieta, A Castellanos-Rubio… - Journal of medical …, 2011 - jmg.bmj.com
Introduction Recent genome wide association studies (GWAS) on coeliac disease (CD)
have identified risk loci harbouring genes that fit the accepted pathogenic model and are …

Ambient temperature and prevalence of obesity in the Spanish population: the D i@ bet. es study

S Valdés, C Maldonado‐Araque, F García‐Torres… - …, 2014 - Wiley Online Library
Objective The aim of this study was to examine possible associations between ambient
temperature and obesity in the Spanish population using an ecological focus. Methods The …

[HTML][HTML] Accuracy in copy number calling by qPCR and PRT: a matter of DNA

N Fernandez-Jimenez, A Castellanos-Rubio… - PloS one, 2011 - journals.plos.org
The possible implication of copy number variation (CNV) in the genetic susceptibility to
human disease needs to be assessed using robust methods that can be applied at a …

Analysis of β-defensin and Toll-like receptor gene copy number variation in celiac disease

N Fernandez-Jimenez, A Castellanos-Rubio… - Human immunology, 2010 - Elsevier
Celiac disease (CD) is an immune-mediated disorder of the gut in which innate and
adaptive responses are involved. Toll-like receptor (TLR) 2 and TLR4 participate in host …

Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA

I Santin, A Castellanos-Rubio, AM Aransay… - Genes & …, 2009 - nature.com
The objective of this study was to identify additional diabetes susceptibility markers in the
MHC that could be responsible for the differential diabetogenicity of different HLA-DR3 …

Factors affecting levels of urinary albumin excretion in the general population of Spain: the Di@ bet. es study

C Gutierrez-Repiso, G Rojo-Martinez… - Clinical …, 2013 - portlandpress.com
The present study was undertaken to examine the prevalence of urinary ACR
(albumin/creatinine ratio)> 30 mg/g and the associated clinical and environmental factors in …