Purpose.—To update the American Society of Clinical Oncology (ASCO)/College of
American Pathologists (CAP) guideline recommendations for human epidermal growth …

Purpose.—To develop a guideline to improve the accuracy of human epidermal growth
factor receptor 2 (HER2) testing in invasive breast cancer and its utility as a predictive …

Purpose.—To update key recommendations of the American Society of Clinical Oncology
(ASCO)/College of American Pathologists (CAP) human epidermal growth factor receptor 2 …

Pretreatment cytogenetics is a known predictor of outcome in hematologic malignancies.
However, its usefulness in adult acute lymphoblastic leukemia (ALL) is generally limited to …

Biospecimens acquired during routine medical practice are the primary sources of molecular
information about patients and their diseases that underlies precision medicine and …

Context.—Intratumoral heterogeneity of HER2 gene amplification has been well
documented and represents subclonal diversity within the tumor. The reported incidence of …

Background Metaphase spreading is an essential technique for clinical and molecular
cytogenetics. Results of classical banding techniques as well as complex fluorescent in situ …

Purpose: Analysis of patients with late relapse (LR) of germ cell tumor (GCT) with reports on
clinical characteristics, outcomes, and molecular and cytogenetic features. Patients and …

Recent studies have implicated α-satellite DNA as an integral part of the centromere,
important for the normal segregation of human chromosomes. To explore the relationship …

We present a case of a child with del (13)(q31. 1qter), VACTERL association, and
penoscrotal transposition. Deletion of the distal long arm of chromosome 13 is associated …