Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …

Coeliac disease is an inflammatory disorder of the small intestine with an autoimmune
component and strong heritability. Genetic studies have confirmed strong association to HLA …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

We performed a second-generation genome-wide association study of 4,533 individuals
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …

Recent work has demonstrated that some functional categories of the genome contribute
disproportionately to the heritability of complex diseases. Here we analyze a broad set of …

Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …

Our genome-wide association study of celiac disease previously identified risk variants in
the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most …

Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to …

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …

Using the Immunochip custom SNP array, which was designed for dense genotyping of 186
loci identified through genome-wide association studies (GWAS), we analyzed 11,475 …