This chapter is a rough map of the book. It provides a concise overview of data-analytic tasks
associated with microarray studies, pointers to chapters that can help perform these tasks …

PURPOSE: Published reports suggest that DNA microarrays identify clinically meaningful
subtypes of lung adenocarcinomas not recognizable by other routine tests. This report is an …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …

Human cancer is caused by the accumulation of mutations in oncogenes and tumor
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we …

There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end …

The elucidation of the human genome sequence has made it possible to identify genetic
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …

To assess changes since the mid-1970s, we reviewed 843 episodes of positive blood
cultures in 707 patients with septicemia. The five most common pathogens were …

Purpose Genetic counseling is now routinely offered to individuals at high risk of carrying a
BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable …

Women with atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), lobular
carcinoma in situ (LCIS), and severe ADH are at increased risk of breast cancer, but a …

Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely
understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number …