Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …

Asthma is caused by a combination of poorly understood genetic and environmental factors,.
We have systematically mapped the effects of single nucleotide polymorphisms (SNPs) on …

THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To
identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases …

The increasing number of DNA polymorphisms characterized in humans will soon allow the
construction of fine genetic maps of human chromosomes. This advance calls for a …

We have created a global map of the effects of polymorphism on gene expression in 400
children from families recruited through a proband with asthma. We genotyped 408,273 …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …