User profiles for "author:Frauke Zipp"

Frauke Zipp

Professor of Neurology, University Medical Center of the Johannes Gutenberg
Verified email at unimedizin-mainz.de
Cited by 31306

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

F Zipp, O Aktas - Trends in neurosciences, 2006 - cell.com
Classical knowledge distinguishes between inflammatory and non-inflammatory diseases of
the brain. Either the immune system acts on the CNS and initiates a damage cascade, as in …

Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica

S Jarius, F Paul, D Franciotta, P Waters… - Nature clinical practice …, 2008 - nature.com
Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects
the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a …

Immunoneuropsychiatry—novel perspectives on brain disorders

K Pape, R Tamouza, M Leboyer, F Zipp - Nature Reviews Neurology, 2019 - nature.com
Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our
cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune …

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis

X Montalban, R Gold, AJ Thompson… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

[PDF][PDF] Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system

J Bruttger, K Karram, S Wörtge, T Regen, F Marini… - Immunity, 2015 - cell.com
During early embryogenesis, microglia arise from yolk sac progenitors that populate the
developing central nervous system (CNS), but how the tissue-resident macrophages are …

[HTML][HTML] Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

CM Lill, JT Roehr, MB McQueen, FK Kavvoura… - PLoS …, 2012 - journals.plos.org
More than 800 published genetic association studies have implicated dozens of potential
risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we …

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

T Prozorovski, U Schulze-Topphoff, R Glumm… - Nature cell …, 2008 - nature.com
Repair processes that are activated in response to neuronal injury, be it inflammatory,
ischaemic, metabolic, traumatic or other cause, are characterized by a failure to replenish …

Green tea epigallocatechin-3-gallate mediates T cellular NF-κB inhibition and exerts neuroprotection in autoimmune encephalomyelitis

O Aktas, T Prozorovski, A Smorodchenko… - The Journal of …, 2004 - journals.aai.org
Recent studies in multiple sclerosis and its animal model, experimental autoimmune
encephalomyelitis (EAE), point to the fact that even in the early phase of inflammation …

[PDF][PDF] In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis

V Siffrin, H Radbruch, R Glumm, R Niesner, M Paterka… - Immunity, 2010 - cell.com
Neuronal damage in autoimmune neuroinflammation is the correlate for long-term disability
in multiple sclerosis (MS) patients. Here, we investigated the role of immune cells in …

MR-elastography reveals degradation of tissue integrity in multiple sclerosis

J Wuerfel, F Paul, B Beierbach, U Hamhaber, D Klatt… - Neuroimage, 2010 - Elsevier
In multiple sclerosis (MS), diffuse brain parenchymal damage exceeding focal inflammation
is increasingly recognized to be present from the very onset of the disease, and, although …