A large genome center's improvements to the Illumina sequencing system

MA Quail, I Kozarewa, F Smith, A Scally, PJ Stephens… - Nature …, 2008 - nature.com
Abstract The Wellcome Trust Sanger Institute is one of the world's largest genome centers,
and a substantial amount of our sequencing is performed with'next-generation'massively …

Canine pyometra

FO Smith - Theriogenology, 2006 - Elsevier
Pyometra, literally meaning pus in the uterus, is a common disease entity of intact bitches.
Similar conditions occur, including hydrometra and mucometra [De Bosschere H, Ducatelle …

[HTML][HTML] Clinical and pathological features of pachyonychia congenita

SA Leachman, RL Kaspar, P Fleckman… - Journal of Investigative …, 2005 - Elsevier
Pachyonychia congenita (PC) is a rare genodermatosis affecting the nails, skin, oral
mucosae, larynx, hair, and teeth. Pathogenic mutations in keratins K6a or K16 are …

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

CNA Palmer, AD Irvine, A Terron-Kwiatkowski, Y Zhao… - Nature …, 2006 - nature.com
Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in
frequency in recent decades and now affects∼ 20% of the population in the developed …

Population genomics of domestic and wild yeasts

G Liti, DM Carter, AM Moses, J Warringer, L Parts… - Nature, 2009 - nature.com
Since the completion of the genome sequence of Saccharomyces cerevisiae in 1996 (refs),
there has been a large increase in complete genome sequences, accompanied by great …

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

FJD Smith, AD Irvine, A Terron-Kwiatkowski… - Nature …, 2006 - nature.com
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization
and one of the most frequent single-gene disorders in humans. The most widely cited …

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

A Sandilands, A Terron-Kwiatkowski, PR Hull… - Nature …, 2007 - nature.com
We recently reported two common filaggrin (FLG) null mutations that cause ichthyosis
vulgaris and predispose to eczema and secondary allergic diseases. We show here that …

Antagonistic coevolution accelerates molecular evolution

S Paterson, T Vogwill, A Buckling, R Benmayor… - Nature, 2010 - nature.com
Abstract The Red Queen hypothesis proposes that coevolution of interacting species (such
as hosts and parasites) should drive molecular evolution through continual natural selection …

Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin‐dependent diabetes mellitus patients

GE Salvi, B Yalda, JG Collins, BH Jones… - Journal of …, 1997 - Wiley Online Library
The gingival crevicular fluid (GCF) and monocytic secretion of prostaglandin E2 (PGE2) and
interleukin 1β (IL‐1β) were measured in a group of 39 insulin‐dependent diabetes mellitus …

The clinical, microbial, and host response characteristics of the failing implant.

JM Salcetti, JD Moriarty, LF Cooper… - … Journal of Oral & …, 1997 - search.ebscohost.com
The goal of this study was to provide new data regarding levels of inflammatory and growth
factor mediators and bacterial pathogens associated with failing implants, as compared to …