[HTML][HTML] The health effects of vitamin D supplementation: evidence from human studies
R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …
Bone fragility in diabetes: novel concepts and clinical implications
Increased fracture risk represents an emerging and severe complication of diabetes. The
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …
[HTML][HTML] Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies
L Ma, L Oei, L Jiang, K Estrada, H Chen… - European journal of …, 2012 - Springer
Type 2 diabetes mellitus (T2DM) influences bone metabolism, but the relation of T2DM with
bone mineral density (BMD) remains inconsistent across studies. The objective of this study …
bone mineral density (BMD) remains inconsistent across studies. The objective of this study …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
EK Speliotes, CJ Willer, SI Berndt, KL Monda… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
H Lango Allen, K Estrada, G Lettre, SI Berndt… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
TJ Wang, F Zhang, JB Richards, B Kestenbaum… - The Lancet, 2010 - thelancet.com
Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …
Systematic identification of trans eQTLs as putative drivers of known disease associations
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta …
overcome this problem, we performed expression quantitative trait locus (eQTL) meta …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
Genome-wide association study of blood pressure and hypertension
Blood pressure is a major cardiovascular disease risk factor. To date, few variants
associated with interindividual blood pressure variation have been identified and replicated …
associated with interindividual blood pressure variation have been identified and replicated …