Background Gene-expression analysis is increasingly important in biological research, with
real-time reverse transcription PCR (RT-PCR) becoming the method of choice for high …

Array-based whole genome investigation or molecular karyotyping enables the genome-
wide detection of submicroscopic imbalances. Proof-of-principle experiments have …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of blood cancer that
accounts for about 15% of pediatric and 25% of adult acute lymphoblastic leukemia (ALL) …

In 2007, the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX)
was identified as a histone demethylase that specifically targets di-and tri-methyl groups on …

MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of
cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly …

Although quantitative PCR (qPCR) is becoming the method of choice for expression profiling
of selected genes, accurate and straightforward processing of the raw measurements …

Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is
largely unknown. Here we show that germline mutations in the anaplastic lymphoma kinase …

Gene expression analysis of microRNA molecules is becoming increasingly important. In
this study we assess the use of the mean expression value of all expressed microRNAs in a …

We took advantage of overlapping interstitial deletions at chromosome 8p11–p12 in two
individuals with contiguous gene syndromes and defined an interval of roughly 540 kb …

Background Duplications and deletions in the human genome can cause disease or
predispose persons to disease. Advances in technologies to detect these changes allow for …