Lissencephaly comprises a heterogeneous group of developmental brain disorders of
varying severity, involving abnormal cortical gyration. We studied a highly consanguineous …

Heparanase is an endo‐β‐d‐glucuronidase that cleaves heparan sulfate (HS) side chains of
heparan sulfate proteoglycans. Compelling evidence tie heparanase levels with all steps of …

Objective: Ovarian adrenal rest tumors (OARTs) are rare in contrast to testicular adrenal rest
tumors. We report a case of OART in a patient with congenital adrenal hyperplasia who …

Background Leflunomide (LEF) is indicated in adults for the treatment of active rheumatoid
arthritis (RA). LEF inhibits dehydroorotate dehydrogenase, a key enzyme of the pyrimidine …

The authors describe the case of a 19-year-old female patient with a primary primitive
neuroectodermal tumor (PNET) of the thoraco-lumbar spinal cord, who presented with acute …

Gliosarcomas are morphologically biphasic tumors composed of glial and sarcomatous
elements. Only rare examples of gliosarcoma with oligodendroglial components have been …

Background Cell survival critically depends on the integrity of mitochondria, which play a
pivotal role during apoptosis. Extensive mitochondrial damage promotes release of pro …

Mature ovarian teratomas rarely undergo transformation into malignancy. Carcinomas,
mostly squamous cell carcinoma, are the most common malignancy arising in mature cystic …

Autoimmune pancreatitis can mimic pancreatic cancer in its clinical presentation, imaging
features and laboratory parameters. Differentiating between those two entities requires …

Amyloidoma is a term referring to a tumor-like deposition of extracellular insoluble fibrillar
protein. Tumor-like amyloid formation in the brain had been described in isolated cases …