User profiles for "author:Els Wauters"
Els WautersVerified email at yappa.be Cited by 7466 |
Trial watch: chemotherapy-induced immunogenic cell death in oncology
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …
death that activates, rather than suppresses, innate and adaptive immune responses. Such …
Phenotype molding of stromal cells in the lung tumor microenvironment
Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
Capmatinib for the treatment of non-small cell lung cancer
JF Vansteenkiste, C Van de Kerkhove… - Expert review of …, 2019 - Taylor & Francis
Introduction: Activation of the MET pathway through MET amplifications or mutations is
present in 3–4% of stage IV non-squamous non-small cell lung cancers (NSCLC). High MET …
present in 3–4% of stage IV non-squamous non-small cell lung cancers (NSCLC). High MET …
[HTML][HTML] Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2
The ongoing COVID-19 pandemic has caused a global economic and health crisis. To
identify host factors essential for coronavirus infection, we performed genome-wide …
identify host factors essential for coronavirus infection, we performed genome-wide …
[HTML][HTML] Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages
How the innate and adaptive host immune system miscommunicate to worsen COVID-19
immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune …
immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune …
[HTML][HTML] A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …
MET is required for the recruitment of anti-tumoural neutrophils
Mutations or amplification of the MET proto-oncogene are involved in the pathogenesis of
several tumours,,,, which rely on the constitutive engagement of this pathway for their growth …
several tumours,,,, which rely on the constitutive engagement of this pathway for their growth …
[HTML][HTML] Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced …
triggering of an aberrant host immune response, more so than on direct virus-induced …
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of
African ancestry compared to women of European ancestry. In search of common risk alleles …
African ancestry compared to women of European ancestry. In search of common risk alleles …
[PDF][PDF] An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …