Gastro‐oesophageal reflux can cause inflammation, metaplasia, dysplasia and cancer of the
oesophagus. Despite the increased use of proton pump inhibitors (PPIs) to treat reflux, the …

BACKGROUND: Obesity and its related illness is a primary health concern today.
METHODS: Five hundred morbidly obese patients (mean age 42 years; mean preoperative …

Background Existing clinical practice guidelines for carriers of pathogenic variants of DNA
mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative …

Objective The use of risk prediction models grows as electronic medical records become
widely available. Here, we develop and validate a model to identify individuals at increased …

Background Recently, three updated guidelines for post‐polypectomy colonoscopy
surveillance (PPCS) have been published. These guidelines are based on a comprehensive …

Background and aim Increased common bile duct (CBD) diameter has been attributed to
aging and previous cholecystectomy. These relationships are, however, controversial and …

Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy | NEJM Skip to main
content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to …

Recent advances have contributed to the understanding of the molecular basis of various
types of colorectal cancer, and among these, the inherited colorectal cancer syndromes …

Background Heterozygous germline mutations in any of the mismatch repair (MMR) genes,
MLH1, MSH2, MSH6, and PMS2, cause Lynch syndrome (LS), an autosomal dominant …

Background Colorectal cancer (CRC) incidence at ages< 50 years is increasing worldwide.
Screening initiation was lowered to 45 years in the United States. The cost‐effectiveness of …