Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …

Angelman syndrome is a neurogenetic disorder characterized by the loss or reduction of the
ubiquitin-protein ligase E3A enzyme. Angelman syndrome results from a deletion or …

The growing interest in cannabidiol (CBD), specifically a pure form of CBD, as a treatment
for epilepsy, among other conditions, is reflected in recent changes in legislation in some …

Summary Background Patients with Lennox-Gastaut syndrome, a rare, severe form of
epileptic encephalopathy, are frequently treatment resistant to available medications. No …

Background The Dravet syndrome is a complex childhood epilepsy disorder that is
associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for …

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease
affecting multiple body systems with wide variability in presentation. In 2013, Pediatric …

The ketogenic diet (KD) is an established, effective nonpharmacologic treatment for
intractable childhood epilepsy. The KD is provided differently throughout the world, with …

Background Tuberous sclerosis complex is a genetic disorder leading to constitutive
activation of mammalian target of rapamycin (mTOR) and growth of benign tumours in …

Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments
for intractable childhood epilepsy. For many years KDTs were implemented differently …

Background: Although epilepsy affects most patients with tuberous sclerosis complex (TSC),
little is known about the natural history of epilepsy in this genetic disease. Methods: A …