Sox proteins are characterized by possession of a DNA-binding domain with similarity to the
high-mobility group domain of the sex determining factor SRY. Here, we report on Sox10, a …

The transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of
their continuous presence during development and in the differentiated state they shape the …

The mechanism that causes neural stem cells in the central nervous system to switch from
neurogenesis to gliogenesis is poorly understood. Here we analyzed spinal cord …

Myelination is an evolutionary recent differentiation program that has been independently
acquired in vertebrates by Schwann cells in the peripheral nervous system and …

Waardenburg syndrome (WS) is an autosomal dominant disorder with an incidence of 1 in
40 000 that manifests with sensorineural deafness and pigmentation defects. It is classified …

The high-mobility-group domain-containing transcription factor Sox11 is expressed
transiently during embryonic development in many tissues that undergo inductive …

The myelin-forming oligodendrocytes are an excellent model to study transcriptional
regulation of specification events, lineage progression, and terminal differentiation in the …

Glial cells of the oligodendrocyte lineage express several highly related POU proteins
including Tst-1/Oct6/SCIP and Brn-1. Tst-1/Oct6/SCIP, but not Brn-1 efficiently cooperated …

During organogenesis, neural and mesenchymal progenitor cells give rise to many cell
lineages, but their molecular requirements for self-renewal and lineage decisions are …

Sox8, Sox9, and Sox10 constitute subgroup E within the Sox family of transcription factors.
Many Sox proteins are essential regulators of development. Sox9, for instance, is required …