Chromosome abnormalities occur with astonishing frequency in humans, being present in
an estimated 10-30% of all fertilized eggs. Of the different classes of chromosome …

The origin of human triploidy is controversial. Early cytogenetic studies found the majority of
cases to be paternal in origin; however, recent molecular analyses have challenged these …

In humans, the relationship between advancing maternal age and the incidence of trisomy
has been long established, but the possible effect of increasing age of the father remains …

Background A study of the prevalence of sperm aneuploidy among pesticide factory workers
was conducted in Anhui, China. Methods We recruited 75 men: 32 subjects from a large …

In humans, deviations from a 1: 1 male: female ratio have been identified in both
chromosomally normal and trisomic live births: among normal newborns there is a slight …

Vascular smooth muscle cells (VSMCs) at capacitance arteries of hypertensive individuals
and animals undergo marked age-and blood pressure–dependent polyploidization and …

Cytogenetic studies on spontaneous abortions traditionally have used one of two
methodologies, direct preparations or long‐term culture, to determine the chromosome …

Despite the clinical importance of human aneuploidy, we know little of the causes of
mammalian non-disjunction. In part, this reflects the fact that, unlike lower organisms …

Vascular smooth muscle cells (VSMC) at capacitance arteries of hypertensive individuals
and animals undergo dramatic polyploidization that contributes toward their hypertrophic …

Recently, there have been several molecular studies of trisomic fetuses and liveborns which
have examined the parent and meiotic stage of origin of nondisjunction. However, little is …