[HTML][HTML] Luteolin: a flavonoid that has multiple cardio-protective effects and its molecular mechanisms

Y Luo, P Shang, D Li - Frontiers in Pharmacology, 2017 - frontiersin.org
Cardiovascular disease (CVD) has become the leading cause of morbidity and mortality
worldwide. A well-monitored diet with a sufficient intake of fruits and vegetables has been …

Effects of the angiotensin‐receptor neprilysin inhibitor on cardiac reverse remodeling: meta‐analysis

Y Wang, R Zhou, C Lu, Q Chen, T Xu… - Journal of the American …, 2019 - Am Heart Assoc
Background The angiotensin‐receptor neprilysin inhibitor (ARNI) sacubitril/valsartan was
shown to be superior to the angiotensin‐converting enzyme inhibitor enalapril in terms of …

Coronary microvascular dysfunction pathophysiology in COVID‐19

J Yin, S Wang, Y Liu, J Chen, D Li, T Xu - Microcirculation, 2021 - Wiley Online Library
Recently, accumulating evidence has highlighted the role of endothelial dysfunction in
COVID‐19 progression. Coronary microvascular dysfunction (CMD) plays a pivotal role in …

Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion

F Fang, D Li, H Pan, D Chen, L Qi, R Zhang, H Sun - Pharmacology, 2011 - karger.com
Luteolin, a naturally occurring polyphenol flavonoid, has demonstrated to exert myocardial
protection effects. However, the mechanisms have not been fully elucidated. In the present …

[HTML][HTML] Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following ischemia/reperfusion

T Xu, D Li, D Jiang - Nutrients, 2012 - mdpi.com
Myocardial ischemia often results in damaged heart structure and function, which can be
restored through ischemia/reperfusion (I/R) in most cases. However, I/R can exacerbate …

[HTML][HTML] JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention

Q Chen, T Xu, D Li, D Pan, P Wu, Y Luo… - American journal of …, 2016 - ncbi.nlm.nih.gov
Recent studies have demonstrated that diabetes impairs the phosphatidylinositol 3-
kinase/Akt (PI3K/Akt) pathway, while insulin resistance syndrome has been associated with …

[HTML][HTML] The anti-apoptotic and cardioprotective effects of salvianolic acid a on rat cardiomyocytes following ischemia/reperfusion by DUSP-mediated regulation of the …

T Xu, X Wu, Q Chen, S Zhu, Y Liu, D Pan, X Chen, D Li - PloS one, 2014 - journals.plos.org
The purpose of this study was to observe the effects of salvianolic acid A (SAA) pretreatment
on the myocardium during ischemia/reperfusion (I/R) and to illuminate the interrelationships …

Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion

S Zhu, T Xu, Y Luo, Y Zhang, H Xuan, Y Ma… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: A major challenge for current therapeutic strategies against
ischemia/reperfusion (I/R) is the lack of effective drugs. Considering luteolin enhances the …

Combination pharmacotherapies for cardiac reverse remodeling in heart failure patients with reduced ejection fraction: a systematic review and network meta-analysis …

J Bao, R Kan, J Chen, H Xuan, C Wang, D Li… - Pharmacological …, 2021 - Elsevier
Pharmacotherapies, including angiotensin-converting enzyme inhibitors (ACEIs),
angiotensin receptor II blockers (ARBs), β-blockers (BBs), mineralocorticoid receptor …

[HTML][HTML] Luteolin modulates SERCA2a via Sp1 upregulation to attenuate myocardial ischemia/reperfusion injury in mice

Y Hu, C Zhang, H Zhu, S Wang, Y Zhou, J Zhao… - Scientific Reports, 2020 - nature.com
The sarco/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) is responsible for calcium
transport during excitation–contraction coupling and is essential for maintaining myocardial …