In this review, we have discussed the class-prediction and discovery methods that are
applied to gene expression data, along with the implications of the findings. We attempted to …

Reactive gliosis is the universal reaction to brain injury, but the precise origin and
subsequent fate of the glial cells reacting to injury are unknown. Astrocytes react to injury by …

Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules
that modulate their quiescence are largely unknown. Here, we show that bone …

Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …

As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity
of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can …

Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X
syndrome, the most common genetic form of mental retardation, a CGG trinucleotide–repeat …

In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The
molecular signals governing neurogenesis in these unique neurogenic niches, however, are …

MERTK is an essential component of the signaling network that controls phagocytosis in
retinal pigment epithelium (RPE), the loss of which results in photoreceptor degeneration …

Background The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor
cells of a subset of breast cancer patients. However, the mechanism that regulates PD-L1 …

Growth cones enable axons to navigate toward their targets by responding to extracellular
signaling molecules. Growth-cone responses are mediated in part by the local translation of …