Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …

Metastatic disease is responsible for the majority of cancer-related deaths, either directly
due to tumor involvement of critical organs or indirectly due to complications of therapy to …

Tumor invasion and metastasis formation are major obstacles for successful cancer therapy.
Metastasis is a complex multistep process that requires sequential interactions between the …

Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus …

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the
absence of a history of significant alcohol use or other known liver disease. Nonalcoholic …

Background Nonalcoholic steatohepatitis is a common liver disease that can progress to
cirrhosis. Currently, there is no established treatment for this disease. Methods We randomly …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …

Background The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a
potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in …

Background & Aims Histologic analysis of liver biopsy specimens allows for grading and
staging of nonalcoholic fatty liver disease (NAFLD). We performed a longitudinal study to …

Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction,–
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …