User profiles for "author:David B Goldstein"

David B. Goldstein

Columbia University
Verified email at columbia.edu
Cited by 93507

Finding the missing heritability of complex diseases

TA Manolio, FS Collins, NJ Cox, DB Goldstein… - Nature, 2009 - nature.com
Genome-wide association studies have identified hundreds of genetic variants associated
with complex human diseases and traits, and have provided valuable insights into their …

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

MI McCarthy, GR Abecasis, LR Cardon… - Nature reviews …, 2008 - nature.com
The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …

Uncovering the roles of rare variants in common disease through whole-genome sequencing

ET Cirulli, DB Goldstein - Nature Reviews Genetics, 2010 - nature.com
Although genome-wide association (GWA) studies for common variants have thus far
succeeded in explaining only a modest fraction of the genetic components of human …

Common variants conferring risk of schizophrenia

H Stefansson, RA Ophoff, S Steinberg, OA Andreassen… - Nature, 2009 - nature.com
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Large recurrent microdeletions associated with schizophrenia

H Stefansson, D Rujescu, S Cichon, OPH Pietiläinen… - nature, 2008 - nature.com
Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

D Ge, J Fellay, AJ Thompson, JS Simon, KV Shianna… - Nature, 2009 - nature.com
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is
the leading cause of cirrhosis in North America. Although the recommended treatment for …

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

DL Thomas, CL Thio, MP Martin, Y Qi, D Ge… - Nature, 2009 - nature.com
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United
States, with estimates of 4 million HCV-infected individuals in the United States and 170 …

A whole-genome association study of major determinants for host control of HIV-1

J Fellay, KV Shianna, D Ge, S Colombo, B Ledergerber… - science, 2007 - science.org
Understanding why some people establish and maintain effective control of HIV-1 and
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole …

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

AK Daly, PT Donaldson, P Bhatnagar, Y Shen, I Pe'er… - Nature …, 2009 - nature.com
Drug-induced liver injury (DILI) is an important cause of serious liver disease. The
antimicrobial agent flucloxacillin is a common cause of DILI, but the genetic basis for …

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

ET Cirulli, BN Lasseigne, S Petrovski, PC Sapp… - Science, 2015 - science.org
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing …