User profiles for "author:David B Goldstein"
David B. GoldsteinColumbia University Verified email at columbia.edu Cited by 93507 |
Finding the missing heritability of complex diseases
TA Manolio, FS Collins, NJ Cox, DB Goldstein… - Nature, 2009 - nature.com
Genome-wide association studies have identified hundreds of genetic variants associated
with complex human diseases and traits, and have provided valuable insights into their …
with complex human diseases and traits, and have provided valuable insights into their …
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …
many common phenotypes of biomedical importance. These advances have been the result …
Uncovering the roles of rare variants in common disease through whole-genome sequencing
ET Cirulli, DB Goldstein - Nature Reviews Genetics, 2010 - nature.com
Although genome-wide association (GWA) studies for common variants have thus far
succeeded in explaining only a modest fraction of the genetic components of human …
succeeded in explaining only a modest fraction of the genetic components of human …
Common variants conferring risk of schizophrenia
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
Large recurrent microdeletions associated with schizophrenia
H Stefansson, D Rujescu, S Cichon, OPH Pietiläinen… - nature, 2008 - nature.com
Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …
pressure on risk alleles and may explain, in part, why common variants have not been found …
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is
the leading cause of cirrhosis in North America. Although the recommended treatment for …
the leading cause of cirrhosis in North America. Although the recommended treatment for …
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United
States, with estimates of 4 million HCV-infected individuals in the United States and 170 …
States, with estimates of 4 million HCV-infected individuals in the United States and 170 …
A whole-genome association study of major determinants for host control of HIV-1
Understanding why some people establish and maintain effective control of HIV-1 and
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole …
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole …
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Drug-induced liver injury (DILI) is an important cause of serious liver disease. The
antimicrobial agent flucloxacillin is a common cause of DILI, but the genetic basis for …
antimicrobial agent flucloxacillin is a common cause of DILI, but the genetic basis for …
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing …
treatment. We report the results of a moderate-scale sequencing study aimed at increasing …