User profiles for "author:DANA LASKO"

Dana Lasko

Self-employed Consultant, Senior Analytical Services Consultant at Design Space …
Verified email at productlife-group.com
Cited by 2611

[HTML][HTML] XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair

CJ Whitehouse, RM Taylor, A Thistlethwaite, H Zhang… - Cell, 2001 - cell.com
XRCC1 protein is required for DNA single-strand break repair and genetic stability but its
biochemical role is unknown. Here, we report that XRCC1 interacts with human …

[HTML][HTML] Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3′-phosphatase and evidence for its role in repair of DNA strand breaks …

A Jilani, D Ramotar, C Slack, C Ong, XM Yang… - Journal of Biological …, 1999 - ASBMB
Mammalian polynucleotide kinases catalyze the 5′-phosphorylation of nucleic acids and
can have associated 3′-phosphatase activity, predictive of an important function in DNA …

[HTML][HTML] Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates

MJ Winton, CI Dubreuil, D Lasko, N Leclerc… - Journal of Biological …, 2002 - ASBMB
The activation state of Rho is an important determinant of axon growth and regeneration in
neurons. Axons can extend neurites on growth inhibitory substrates when Rho is inactivated …

Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.

DE Barnes, LH Johnston, K Kodama… - Proceedings of the …, 1990 - National Acad Sciences
Human cDNA clones encoding the major DNA ligase activity in proliferating cells, DNA
ligase I, were isolated by two independent methods. In one approach, a human cDNA library …

Eukaryotic DNA ligases

DD Lasko, AE Tomkinson, T Lindahl - Mutation Research/DNA Repair, 1990 - Elsevier
Recent studies on eukaryotic DNA ligases are briefly reviewed. The two distinguishable
enzymes from mammalian cells, DNA ligase I and DNA ligase II, have been purified to …

[HTML][HTML] Mammalian DNA ligases. Catalytic domain and size of DNA ligase I.

AE Tomkinson, DD Lasko, G Daly, T Lindahl - Journal of Biological …, 1990 - Elsevier
DNA ligase I is the major DNA ligase activity in proliferating mammalian cells. The protein
has been purified to apparent homogeneity from calf thymus. It has a monomeric structure …

Role of molecular diagnostic testing in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer families

R Rabelo, W Foulkes, PH Gordon… - Diseases of the colon …, 2001 - journals.lww.com
PURPOSE: Genetic tests are available for familial adenomatous polyposis and hereditary
nonpolyposis colorectal cancer. The goal of this review was to develop an algorithm for …

Genetic counseling and interpretation of genetic tests in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer

N Wong, D Lasko, R Rabelo, L Pinsky… - Diseases of the colon …, 2001 - journals.lww.com
PURPOSE: Genetic counseling and interpreting genetic test results can be complex.
Moreover, without knowing the limitations of the methods used and the lifetime probability of …

Activation of mammalian DNA ligase I through phosphorylation by casein kinase II.

C Prigent, DD Lasko, K Kodama, JR Woodgett… - The EMBO …, 1992 - embopress.org
Mammalian DNA ligase I has been shown to be a phosphoprotein. Dephosphorylation of
purified DNA ligase I causes inactivation, an effect dependent on the presence of the N …

Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12–21: exclusion of candidate genes EDH17B2 and RARA

J Simard, J Feunteun, G Lenoir, P Tonin… - Human molecular …, 1993 - academic.oup.com
A susceptibility gene for hereditary breast-ovarian cancer, BRCA1, has been assigned by
linkage analysis to chromosome 17q21. Candidate genes in this region Include EDH17B2 …