User profiles for "author:D M Kullmann"
Dimitri M KullmannProfessor of Neurology, UCL Verified email at ion.ucl.ac.uk Cited by 22675 |
Tonically active GABAA receptors: modulating gain and maintaining the tone
A Semyanov, MC Walker, DM Kullmann… - Trends in neurosciences, 2004 - cell.com
GABA A receptors not only respond to the local release of GABA from presynaptic terminals,
but can also mediate a persistent 'tonic current'. This reflects the activation of high-affinity …
but can also mediate a persistent 'tonic current'. This reflects the activation of high-affinity …
A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
Abstract Episodic ataxia type 1 (EA1) is a rare autosomal dominant disorder characterized
by brief episodes of ataxia associated with continuous interattack myokymia. Point mutations …
by brief episodes of ataxia associated with continuous interattack myokymia. Point mutations …
[HTML][HTML] Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why?
Although GABAA receptors are widely distributed at inhibitory synapses on dendrites and
cell bodies of neurons, they also occur in other places, in particular at synapses made on …
cell bodies of neurons, they also occur in other places, in particular at synapses made on …
N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both …
Antibodies to the N-methyl-d-aspartate subtype of glutamate receptor have been associated
with a newly-described encephalopathy that has been mainly identified in young females …
with a newly-described encephalopathy that has been mainly identified in young females …
Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation
DA Rusakov, DM Kullmann - Journal of Neuroscience, 1998 - Soc Neuroscience
Fast excitatory synapses are generally thought to act as private communication channels
between presynaptic and postsynaptic neurons. Some recent findings, however, suggest …
between presynaptic and postsynaptic neurons. Some recent findings, however, suggest …
GABA uptake regulates cortical excitability via cell type–specific tonic inhibition
A Semyanov, MC Walker, DM Kullmann - Nature neuroscience, 2003 - nature.com
GABAA receptors can mediate both'phasic'synaptic inhibition and a persistent'tonic'form of
signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal …
signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal …
Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel
A Jouvenceau, LH Eunson, A Spauschus, V Ramesh… - The Lancet, 2001 - thelancet.com
Background The genetic basis of most common forms of human paroxysmal disorders of the
central nervous system, such as epilepsy, remains unidentified. Several animal models of …
central nervous system, such as epilepsy, remains unidentified. Several animal models of …
[PDF][PDF] Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake
F Asztely, G Erdemli, DM Kullmann - Neuron, 1997 - cell.com
At excitatory synapses on CA1 pyramidal cells of the hippocampus, a larger quantal content
is sensed by N-methyl-D-aspartic acid receptors (NMDARs) than by α-amino-3-hydroxy-5 …
is sensed by N-methyl-D-aspartic acid receptors (NMDARs) than by α-amino-3-hydroxy-5 …
Long-term synaptic plasticity in hippocampal interneurons
DM Kullmann, KP Lamsa - Nature Reviews Neuroscience, 2007 - nature.com
Rapid memory formation relies, at least in part, on long-term potentiation (LTP) of excitatory
synapses. Inhibitory interneurons of the hippocampus, which are essential for information …
synapses. Inhibitory interneurons of the hippocampus, which are essential for information …
A genetically encoded fluorescent sensor for in vivo imaging of GABA
Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop …
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop …