Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor
(VEGF) A is a key signal in the induction of vessel growth (a process termed angiogenesis) …

The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

It is anticipated that by 2040 neurodegeneration will affect 40 million people worldwide,
more than twice as many as today. The traditional neurocentric view holds that …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Background Following the discovery that mutant KRAS is associated with resistance to anti-
epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Summary Background In the Medical Research Council (MRC) COIN trial, the epidermal
growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard …

Therapeutic angiogenesis is likely to require the administration of factors that complement
each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial …

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …