User profiles for "author:D Lambrechts"
Diether LambrechtsLaboratory for Translational Genetics, Department of Oncology, VIB and KULeuven, Leuven … Verified email at vib-kuleuven.be Cited by 64155 |
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor
(VEGF) A is a key signal in the induction of vessel growth (a process termed angiogenesis) …
(VEGF) A is a key signal in the induction of vessel growth (a process termed angiogenesis) …
Role and therapeutic potential of VEGF in the nervous system
C Ruiz de Almodovar, D Lambrechts… - Physiological …, 2009 - journals.physiology.org
The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …
evolution of the animal kingdom; the former provides electrical stimuli and coordination …
Neurovascular signalling defects in neurodegeneration
S Zacchigna, D Lambrechts, P Carmeliet - Nature Reviews …, 2008 - nature.com
It is anticipated that by 2040 neurodegeneration will affect 40 million people worldwide,
more than twice as many as today. The traditional neurocentric view holds that …
more than twice as many as today. The traditional neurocentric view holds that …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
…, A Ziegler, I Buysschaert, D Lambrechts… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a …
…, E Van Cutsem, H Piessevaux, D Lambrechts… - The lancet …, 2010 - thelancet.com
Background Following the discovery that mutant KRAS is associated with resistance to anti-
epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic …
epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic …
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
…, X Wang, C Vachon, KN Stevens, D Lambrechts… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …
been identified as associated with susceptibility to breast cancer, and these account for∼ …
[HTML][HTML] Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 …
…, J Bridgewater, MJ Kennedy, B Claes, D Lambrechts… - The Lancet, 2011 - thelancet.com
Summary Background In the Medical Research Council (MRC) COIN trial, the epidermal
growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard …
growth factor receptor (EGFR)-targeted antibody cetuximab was added to standard …
Role of PlGF in the intra-and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
…, D Communi, A Kranz, L Moons, D Lambrechts… - Nature medicine, 2003 - nature.com
Therapeutic angiogenesis is likely to require the administration of factors that complement
each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial …
each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial …
Phenotype molding of stromal cells in the lung tumor microenvironment
Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …