Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is characterized
by benign tumors (hamartomas and hamartias) involving multiple organ systems, due to …

Over the past decade, there has been considerable progress in understanding the
molecular genetics of tuberous sclerosis, a disorder characterised by hamartomatous …

Several new members of the gelsolin family have been discovered in the past year.
Determination of the structure of gelsolin and identification of lysophosphatidic acid as a …

We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the
widespread development of distinctive tumors termed hamartomas. TSC-determining loci …

Background Tuberous sclerosis complex is highly variable in clinical presentation and
findings. Disease manifestations continue to develop over the lifetime of an affected …

Importance Targeting oncogenic drivers (genomic alterations critical to cancer development
and maintenance) has transformed the care of patients with lung adenocarcinomas. The …

Objective To establish evidence-based recommendations for the molecular analysis of lung
cancers that are that are required to guide EGFR-and ALK-directed therapies, addressing …

The caspase-3 (CPP32, apopain, YAMA) family of cysteinyl proteases has been implicated
as key mediators of apoptosis in mammalian cells. Gelsolin was identified as a substrate for …